Antimycin complex

Antimycin complex

$63.00 - 5 mg

$221.00 - 25 mg

All prices in Australian dollars

Code
BIA-A1374
Synonyms
Antipiriculin, Levoristatin, Virosin, Vulgarin
CAS #
1397-94-0
Molecular Formula
C28H40N2O9 (for A1)
Molecular Weight
548.6 (for A1)
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Application Notes

Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.

References

  • The isolation and properties of antimycin A. Bryant R. & Dunshee B.R. et al., J. Am. Chem. Soc. 1949, 71, 2436.
  • Inhibition of electron transport by antimycin A, alkyl hydroxy naphthoquinones and metal coordination compounds. Tappel A.L. Biochem. Pharmacol. 1960, 3, 289.
  • Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production. Yan Y. et al., Org. Lett. 2012, 14, 4142.

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