$63.00 - 5 mg
$221.00 - 25 mg
All prices in Australian dollars
- Antipiriculin, Levoristatin, Virosin, Vulgarin
- CAS #
- Molecular Formula
- C28H40N2O9 (for A1)
- Molecular Weight
- 548.6 (for A1)
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.
- The isolation and properties of antimycin A. Bryant R. & Dunshee B.R. et al., J. Am. Chem. Soc. 1949, 71, 2436.
- Inhibition of electron transport by antimycin A, alkyl hydroxy naphthoquinones and metal coordination compounds. Tappel A.L. Biochem. Pharmacol. 1960, 3, 289.
- Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production. Yan Y. et al., Org. Lett. 2012, 14, 4142.