Ansamitocin P3

Ansamitocin P3

$166.00 - 0.10 mg

$581.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-A2536
Synonyms
Ansamitosin P 3, Antibiotic C 15003P3, Maytansinol isobutyrate, NSC 292222
CAS #
66584-72-3
Molecular Formula
C32H43ClN2O9
Molecular Weight
635.14
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

Ansamitocins, a new group of ansamycin antibiotics with potent antitumor activity, were first reported in the journal Nature in 1977 by researchers from Takeda Chemical Industries. Anisomitocin P3 is the 3-O-methylpropanoyl derivative of maytansinol produced by bacteria rather than maytansinoid-producing plants. Ansamitocin P3 inhibits the growth of several eukaryotic microorganisms but has no activity against prokaryotic microorganisms. The acyl moieties at the C-3 position of ansamitocins are essential for their antifungal activities. Ansamitocin P3 targets cell division protein FtsZ, the analogue of β-tubulin in bacteria.

References

  • Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia. Higashide E. et al. Nature 1977, 270, 721.
  • Ansamitocins, maytansinoid antitumor antibiotics: Producing organism, fermentation, and antimicrobial activities. Tanida S. et al. J. Antibiot. 1980, 33, 192.
  • Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro. Ootsu K. et al. Cancer Res 1980, 40, 1707.

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