Anagyrine

Anagyrine

$240.00 - 1 mg

$840.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1939
Synonyms
(-)-Anagyrine, (-)-Rhombinine, Monolupin, Monolupine, Rhombinin, Rhombinine
CAS #
486-89-5
Molecular Formula
C15H20N2O
Molecular Weight
244.33
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

Anagyrine is a teratogenic quinolizidine alkaloid found in Lupinus sp. which undergoes metabolism to a piperidine that causes crooked calf syndrome. Anagyrine, but not lupanine or sparteine, directly desensitize nicotinic acetylcholine receptors (nAChR) in a cell culture model. Anagyrine is reported to have antiarrhythmic, tachycardic, diuretic and purgative properties. Extracts containing anagyrine have antifungal activity.

References

  • Lupin alkaloids from teratogenic and nonteratogenic lupins. IV. Concentration of total alkaloids, individual major alkaloids, and the teratogen anagyrine as a function of plant part and stage of growth and their relationship to crooked calf disease. Keeler R.F. et al. J. Tox. Env. Health 1976, 1, 899.
  • Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Green B.T. et al. Res Vet Sci 2017, 115, 195.
  • Antifungal activity of the alkaloids extracts from aerial parts of Retama monosperma. El Handani N. et al. Res J Pharm Biol Chem Sci 2016, 7, 965.

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