Amycolatopsin B is a glycosylated polyketide isolated by Microbial Screening Technologies. The amycolatopsins are closely related to the ammocidins and apoptolidins. Amycolatopsin A and C, bearing a hydroxyl group at the 6-methyl position, selectively inhibit the mycobacteria, M. bovis and M. tuberculosis and exhibit a low level of cytotoxicity toward mammalian cells.
- Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494. Khalil Z.G. et al. J. Antibiot. 2017, 70, 1097.