Ambuic acid

Ambuic acid

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-A2563
Synonyms
(+)-Ambuic acid
CAS #
340774-69-8
Molecular Formula
C19H26O6
Molecular Weight
350.41
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Ambuic acid is an antifungal cyclohexanone metabolite produced by Pestalotiopsis sp. Ambuic acid inhibits the biosynthesis of quorum sensing peptides in Gram-positive bacteria. Ambuic acid may exert anti-​inflammatory action by blocking the activation of the ERK​/JNK MAPK signaling pathway, without the involvement of the p38 MAPK or NF-​κB signaling pathways. Ambuic acid demonstrates potent antiproliferative activity.

References

  • Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp. Li J.Y. et al. Phytochem. 2001, 56, 463.
  • Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria. Jiro N. et al. Antimicrob. Agents Chemother. 2009, 53, 580.
  • Anti-​inflammatory action of ambuic acid, a natural product isolated from the solid culture of Pestalotiopsis neglecta, through blocking ERK​/JNK mitogen-​activated protein kinase signaling pathway. Zhang Q. et al. Exp. Ther. Med. 2018, 16, 153.

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