Ambuic acid

Ambuic acid

$221.00 - 1 mg

$774.00 - 5 mg

All prices in Australian dollars

Synonyms
(+)-Ambuic acid
CAS #
340774-69-8
Molecular Formula
C19H26O6
Molecular Weight
350.41
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Ambuic acid is an antifungal cyclohexanone metabolite produced by Pestalotiopsis sp. Ambuic acid inhibits the biosynthesis of quorum sensing peptides in Gram-positive bacteria. Ambuic acid may exert anti-​inflammatory action by blocking the activation of the ERK​/JNK MAPK signaling pathway, without the involvement of the p38 MAPK or NF-​κB signaling pathways. Ambuic acid demonstrates potent antiproliferative activity.

References

  • Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp. Li J.Y. et al. Phytochem. 2001, 56, 463.
  • Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria. Jiro N. et al. Antimicrob. Agents Chemother. 2009, 53, 580.
  • Anti-​inflammatory action of ambuic acid, a natural product isolated from the solid culture of Pestalotiopsis neglecta, through blocking ERK​/JNK mitogen-​activated protein kinase signaling pathway. Zhang Q. et al. Exp. Ther. Med. 2018, 16, 153.

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