Acivicin

Acivicin

$158.00 - 0.10 mg

$553.00 - 0.50 mg

All prices in Australian dollars

Synonyms
AT 125, Antibiotic AT 125, NSC 163501, U 42126
CAS #
42228-92-2
Molecular Formula
C5H7ClN2O3
Molecular Weight
178.57
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

Download Data Sheets

Product Data Sheet

Application Notes

Acivicin is a chlorinated amino acid originally isolated from Streptomyces sviceus that inhibits glutmate metabolism. It has antitumor and antileishmanial properties. Acivicin competitively inhibits amidophosphoribosyl-transferase, CTP synthetase and carbamoyl-phosphate synthetase II from extracts of liver and hepatoma 3924A, and inhibits ALDH4A1.

References

  • Multi-enzyme-targeted chemotherapy by acivicin and actinomycin. Weber G. et al. Adv Enzyme Regul. 1982, 20, 75.
  • Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Kruezer J. et al. Chem. Sci. 2015, 6, 237.
  • Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis. Mukherjee T. et al. Biochem Biophys Res Commun. 1990, 170, 426

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