Acetylchrysomycin A, 4′-
Application Notes
4’-Acetylchrysomycin A and its co-metabolite, 4’-acetylchrysomycin B, were isolated during a screen for antitumor agents. Acetylation of chyrsomycin A reduces cytotoxicity, although both are highly potent (IC50s 64 μg ml-1 for 4'-acetylchrysomycin A and B, respectively.
References
- Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and B. Wada S. et al. J. Antibiot. 2017, 70, 1078.