Acetomycin

Acetomycin

$189.00 - 0.50 mg

$662.00 - 2.50 mg

All prices in Australian dollars

Synonyms
(-)-Acetomycin, NSC 350598
CAS #
510-18-9
Molecular Formula
C10H14O5
Molecular Weight
214.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMSO or methanol
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Application Notes

Acetomycin, γ-butyrolactone isolated from Streptomyces ramulosus, was first reported in 1958 by Ettlinger et al. at ETH Zurich. Acetomycin is potently active in vitro against HCT-8 human colon adenocarcinoma cells and L1210 murine leukemia cells. Acetomycin is inactive in vivo giving rise to the design and synthesis of esterase-resistant analogues.

References

  • Stoffwechselprodukte von Actinomyceten. 12. Mitteilung. Über die Isolierung und Charakterisierung von Acetomycin. Ettlinger L. et al. Helv. Chim. Acta 1958, 41, 216.
  • Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo. Mamber S.W. et al. J. Antibiot. 1987, 40, 73.
  • Biological effects of acetomycin. II. Inactivation by esterases in vitro. Mamber S.W. et al. J. Antibiot. 1987, 40, 77.

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