$158.00 - 5 mg
$553.00 - 25 mg
All prices in Australian dollars
- 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, AIC-Riboside, AICA-Riboside, AICAr, Acadra, Arasine, GP 1-110, NSC 105823
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Sluble in water and DMSO
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Acadesine was originally identified as a metabolite of Bacillus species and was shown to accumulate in the culture medium of E. coli under sulphonamide stasis. Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine. Ithas been tested clinically as a cardioprotectant and for hematologic malignancies. Acadesine activates AMP-activated protein kinase and inhibits platelet aggregation, induces p53-dependendent apoptosis in B cells and regulates cellular uptake of glucose, beta-oxidation of fatty acids, protein synthesis, and the biogenesis of GLUT4 and mitochondria.
- 5(4)-Amino-4(5)imidazolecarboxamide, a precursor of purines. Shive W. et al. J Am Chem Soc. 1947, 69, 725.
- Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Mullane K. Cardiovascular Res. 1993, 27, 43.
- AICAR antiproliferativepropertiesinvolve the AMPK-independent activation of the tumor suppressors LATS 1 and 2. Chloe P. et al. Neoplasia 2018, 20, 555.