Acadesine

Acadesine

$158.00 - 5 mg

$553.00 - 25 mg

All prices in Australian dollars

Synonyms
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, AIC-Riboside, AICA-Riboside, AICAr, Acadra, Arasine, GP 1-110, NSC 105823
CAS #
2627-69-2
Molecular Formula
C9H14N4O5
Molecular Weight
258.23
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Sluble in water and DMSO
Clear

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Application Notes

Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine that has been tested clinically for cardioprotective indications and hematologic malignancies. Acadesine activates AMP-activated protein kinase and inhibits platelet aggregation, induces p53-dependendent apoptosis in B cells and regulates cellular uptake of glucose, beta-oxidation of fatty acids, protein synthesis, and the biogenesis of GLUT4 and mitochondria.

References

  • Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Mullane K. Cardiovascular Res. 1993, 27, 43.
  • AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2. Chloe P. et al. Neoplasia 2018, 20, 555.
  • Acadesine, an adenosine-regulating agent with the potential for widespread indications. Drew B.G. and Kingwell B.A. Expert Opin Pharmacother. 2008, 9, 2137.

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