PF1163B

PF1163B

$225.00 - 0.50 mg

$790.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-P1704
CAS #
258871-60-2
Molecular Formula
C27H43NO5
Molecular Weight
461.63
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

PF1163B is an unusual 13-membered depsipeptide isolated from an undescribed species of Pencillium by researchers at Meiji Seika Kaisha and reported in 2000 as an antifungal active. The macrocycle of PF1163B comprises a modified N-methyltyrosine conjugated with a 9-hydroxytetradecanoic acid. Structurally, PF1163B is the dehydroxy analogue of the more polar PF1163A. PF1163B is a selective antifungal agent with low mammalian toxicity. PF1163B acts on ergosterol biosynthesis, inhibiting C-4 sterol methyl oxidase, and acts synergistically with fluconazole against azole resistant Candida albicans.

References

  • PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities. Hiroshi N. et al., J. Antibiot. 2000, 53, 33.
  • PF1163A and B, new antifungal antibiotics produced by Penicillium sp. Part II. Physico-chemical properties and structure elucidation. Sasaki T. et al., J. Antibiot. 2000, 53, 38.
  • PF1163A, a novel antifungal agent, inhibits ergosterol biosynthesis at C-4 sterol methyl oxidase. Nose H. et al., J. Antibiot. 2002, 55, 969.

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