Zearalenone

Zearalenone

$131.00 - 5 mg

$459.00 - 25 mg

All prices in Australian dollars

Synonyms
Mycotoxin F2, Toxin F2
CAS #
17924-92-4
Molecular Formula
C18H22O5
Molecular Weight
318.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Zearalenone is a resorcylic acid lactone produced by a number of Fusarium sp. Zearalenone acts as a non-steroidal estrogen, binding to estrogen receptor and is uterotropic. Zearalenone induces reproductive problems in animals and, in some animal models, is thought to be a primary initiator of hepatic tumors. In vivo, zearalenone undergoes metabolic reduction to the more estrogenic zearalenol. Contamination of grains, notably maize, by Fusarium species gives rise to high levels of zearalenone and is regarded as an important food quality issue for both human and animal health.

References

  • Identification of the naturally occuring isomer of zearalenol produced by Fusarium roseum 'Gibbosum' in rice culture. Hagler W.M. et al., Appl. Environ. Microbiol. 1979, 37, 849.
  • Estrogenic activity of zearalenone and zearalenol in the neonatal rat uterus. Teratology 1984, 90, 383-392.
  • Binding properties of zearalenone mycotoxins to hepatic estrogen receptors. Powell-Jones W. et al., Mol. Pharmacol. 1981, 20, 35-42.
  • Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Zinedine A. et al., Food Chem. Toxicol. 2007, 45, 1.

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