Wortmannin

Wortmannin

$100.00 - 1 mg

$350.00 - 5 mg

All prices in Australian dollars

Synonyms
KY 12420
CAS #
19545-26-7
Molecular Formula
C23H24O8
Molecular Weight
428.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumor and Anti-inflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo.

References

  • The structure of wortmannin, a steroidal fungal metabolite. MacMillan J. et al., Chem. Commun. 1968, 613.
  • Activation of human neutrophil phospholipase D by three separable mechanisms. Reinhold S. et al., FASEB J. 1990, 4, 208.
  • Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil. Bonser R.W. et al., Br. J. Pharmacol. 1991, 103, 1237.
  • Wortmannin, a microbial product inhibitor of myosin light chain kinase. Nakanishi S. et al., J. Biol. Chem. 1992, 267, 2157.
  • Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Arcaro A. & Wyman M.P., Biochem. J. 1993, 296, 297.

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