WF 3681

WF 3681

$158.00 - 0.10 mg

$553.00 - 0.50 mg

All prices in Australian dollars

Synonyms
(±)-WF 3681
CAS #
105364-56-5
Molecular Formula
C13H12O5
Molecular Weight
248.23
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

WF 3681 was isolated from Chaetomella sp. as a novel inhibitor of aldose reductase by researchers at Fujisawa Co. Japan in 1987, exhibiting an IC50 of 2.5 x 10-7 M. WF 3681 does not significantly reduce accumulation of sorbitol in rat sciatic nerves of diabetic rats. The structure of WF 3681 was confirmed in 1988.

References

  • Studies on WF-3681, a novel aldose reductase inhibitor. I. Taxonomy, fermentation, isolation and characterization. Nishikawa M. et al. J Antibiot. 1987, 40, 1394.
  • Studies on WF-3681, a novel aldose reductase inhibitor. III. Effect of WF-3681 and its derivatives on sorbitol accumulation in diabetic rats. Nishikawa M. et al. J Antibiot. 1990, 43, 1186.
  • Structure of WF-​3681, 3-​(2,​5-​dihydro-​4-​hydroxy-​5-​oxo-​3-​phenyl-​2-​furyl)​propionic acid. Kissinger C.R. et al. Acta crystallographica. Section C, Crystal Structure Comm. 1988, 44, 512.  

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