WF 3681 was isolated from Chaetomella sp. as a novel inhibitor of aldose reductase by researchers at Fujisawa Co. Japan in 1987, exhibiting an IC50 of 2.5 x 10-7 M. WF 3681 does not significantly reduce accumulation of sorbitol in rat sciatic nerves of diabetic rats. The structure of WF 3681 was confirmed in 1988.
- Studies on WF-3681, a novel aldose reductase inhibitor. I. Taxonomy, fermentation, isolation and characterization. Nishikawa M. et al. J Antibiot. 1987, 40, 1394.
- Studies on WF-3681, a novel aldose reductase inhibitor. III. Effect of WF-3681 and its derivatives on sorbitol accumulation in diabetic rats. Nishikawa M. et al. J Antibiot. 1990, 43, 1186.
- Structure of WF-3681, 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid. Kissinger C.R. et al. Acta crystallographica. Section C, Crystal Structure Comm. 1988, 44, 512.