WEB 2086

WEB 2086

$158.00 - 0.10 mg

$553.00 - 0.50 mg

All prices in Australian dollars

Synonyms
Apafant, WEB 2086BS, Web 2086
CAS #
105219-56-5
Molecular Formula
C22H22ClN5O2S
Molecular Weight
455.96
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

WEB 2086 (apafant) is a potent and selective platelet activating (PAF) antagonist. WEB 2086 has high affinity for guinea pig peritoneal macrophage PAF receptors, dissociating slowly. WEB 2086 at 10-8 to 10-6 mol​/L strongly and concentration-​dependently inhibits PAF-​induced chemotaxis in guinea pig eosinophils. In animal models, WEB 2086 (0.1% w/v) blocks eosinophil activation in allergic conjunctivitis and inhibits the hypotensive and lethal effect of PAF in the rat in a dose-​related manner.

References

  • Pharmacological characterization of a receptor for platelet-​activating factor on guinea pig peritoneal macrophages using [3H]​apafant, a selective and competitive platelet-​activating factor antagonist: evidence that the noncompetitive behavior of apafant in functional studies relates to slow kinetics of dissociation. Ring P. et al. Molec Pharmacol. 1993, 43, 302.
  • Eosinophil chemotaxis induced by several biologically active substances and the effects of apafant on it in vitro. Nabe. Arzneimittel-Forschung 1997, 47, 1112.
  • Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. Kato M. et al. J Pharmacol Sci. 2004, 95, 435.

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