Virginiamycin S1

Virginiamycin S1

$287.00 - 5 mg

$1,005.00 - 25 mg

All prices in Australian dollars

Synonyms
Staphylomycin S, PA 114B2, Antibiotic 899, A1745Z3B, Factor S
CAS #
23152-29-6
Molecular Formula
C43H49N7O10
Molecular Weight
823.9
Purity
>99% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Clear

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Application Notes

Virginiamycin S1 is one of a family of depsipeptide antibiotics co-produced with ostreogrycin A and used as a synergistic mixture. Virginiamycin S1, also known as Staphylomycin S and Factor S among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A. Virginiamycin S1 differs from virginiamycin B in lacking the dimethylamino moiety on the phenyl ring.

References

  • The structures of the minor components of virginiamycin S. Vanderhaeghe, H. et al., Tet. Lett. 1971, 2687.
  • Virginiamycin: nomenclature. Crooy P. and De Neys R. J. Antibiot. 1972, 25, 371.
  • A new species of Streptomyces producing virginiamycin family antibiotics. Ogata, K. et al., J. Antibiot. 1978, 31, 1313.

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