Verlamelin A
Application Notes
Verlamelin A is a complex lipodepsipeptide antibiotic first isolated from Lecanicillium sp. by Nihira and co-workers at Mahidol University Thailand in 2014. Verlamelin A is active against phytopathogenic fungi, including Aspergillus versicolor and Curvularia australiensis. Verlamelin A is also a potent inhibitor of Colletotrichum asianum (MIC 5-10 μg/mL). Verlamelin A is active against HSV-1 with an IC50 of 16.7 μM.
References
- Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp.. Ishidoh K. et al. J Antibiot 2014, 67, 459.
- Antifungal and antiviral cyclic peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020. Liang X. et al. J Ag Food Chem 2017, 65, 5114.
- Peptides from the soft coral-associated fungus Simplicillium sp. SCSIO41209. Dai Y. et al. Phytochem 2018, 154, 56.