UK-1

UK-1

$290.00 - 1 mg

$1,014.00 - 5 mg

All prices in Australian dollars

Code
BIA-U1290
CAS #
151271-53-3
Molecular Formula
C22H14N2O5
Molecular Weight
386.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Limited solubility in ethanol and methanol. Poor water solubility.
Clear

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Application Notes

UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumor activity but is devoid of antimicrobial activity. UK-1 acts as a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II.

References

  • UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physicochemical and biological properties. Ueki M. et al., J. Antibiot. 1993, 46, 1089.
  • UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II Structure elucidation. Shibata K. J. Antibiot. 1993, 46, 1095.
  • The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II. Reynolds M. B. et al., Bioorg. Chem. 1999, 27, 326.

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