$290.00 - 1 mg
$1,014.00 - 5 mg
All prices in Australian dollars
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in DMF or DMSO. Limited solubility in ethanol and methanol. Poor water solubility.
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UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumor activity but is devoid of antimicrobial activity. UK-1 acts as a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II.
- UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physicochemical and biological properties. Ueki M. et al., J. Antibiot. 1993, 46, 1089.
- UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II Structure elucidation. Shibata K. J. Antibiot. 1993, 46, 1095.
- The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II. Reynolds M. B. et al., Bioorg. Chem. 1999, 27, 326.