Tropodithietic acid

Tropodithietic acid

$154.00 - 0.10 mg

$541.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-T1899
CAS #
750590-18-2
Molecular Formula
C8H4O3S2
Molecular Weight
212.25
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Tropodithietic acid is a potent antibiotic isolated from a Roseobacter strain by Brinkhoff and colleagues at the University of Gottingen, Germany in 2004. Tropodithietic acid is a strong inhibitor of marine bacteria, promoter of algal health and a potent quorum sensing regulator. Tropodithietic acid is a tropone that exists as an interconverting tautomer with thiotropocin, itself isolated in the 1980s as a metabolite from a strain of Pseudomonas. Tropodithietic acid has potent, broad-spectrum anticancer activity, acting via a mechanism similar to polyether antibiotics.

References

  • Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its antagonistic effects on indigenous isolates. Brinkhoff T. et al., App. Env. Microbiol. 2004, 70, 2560.
  • Computational studies of the tropone natural products, thiotropocin, tropodithietic acid, and troposulfenin. Significance of thiocarbonyl-enol tautomerism. Greer E.M. et al., J. Org. Chem. 2008, 73, 280.
  • Thiotropocin, a new sulfur-containing 7-membered-ring antibiotic produced by a Pseudomonas sp. Kintaka K. et al., J. Antibiot. 1984, 37, 1294.

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