Toxoflavin

Toxoflavin

$96.00 - 1 mg

$336.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1522
Synonyms
1-Methylreumycin, PKF118-310, Xanthrothricin
CAS #
84-82-2
Molecular Formula
C7H7N5O2
Molecular Weight
193.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Application Notes

Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

References

  • Van Damme P.A. et al., Rec. Trav. Chim. 1960, 79, 255 (1960).
  • On the biosynthesis of toxoflavin, an azapteridine antibiotic produced by Pseudomonas cocovenenans. Levenberg B. & Linton S.N. J. Biol. Chem. 1966, 241, 846.
  • Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Wei W. et al., Int J. Cancer. 2010, 126, 2426.

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