Tigecycline

Tigecycline

$82.00 - 1 mg

$287.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1371
Synonyms
Glycylcycline, GAR 936, 9-t-Butylglycylamidominocycline
CAS #
220620-09-7
Molecular Formula
C29H39N5O8
Molecular Weight
585.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Tigecycline is a semi-synthetic tetracycline prepared by the introduction of a tert-butylaminoacetamido group into a previously unexplored and unsubstituted region of existing tetracyclines. Like other tetracyclines, tigecycline acts by reversibly binding to the 30S ribosomal subunit and inhibits protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. The enhanced activity can be attributed to stronger binding affinity, thus minimising the impact of existing mechanisms of resistance. Tigecycline is regarded as the first of a new class of glycylcyline antibiotics. Critical comparison to the tetracycline class appears to be lacking in the literature.

References

  • Synthesis and antibacterial activity of 9-substituted minocycline derivatives. Suma P-E. et al., Bioorg. Med. Chem. Lett. 2006, 16, 400.
  • Tigecycline: First of a new class of antimicrobial agents. Rose W.E. & Rybak M.J. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 2006, 26, 1099.

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