Thaxtomin A

Thaxtomin A

$175.00 - 0.25 mg

$615.00 - 1 mg

All prices in Australian dollars

Code
BIA-T1911
Synonyms
MBI 005, Thaxtomine A
CAS #
122380-18-1
Molecular Formula
C22H22N4O6
Molecular Weight
438.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water

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Application Notes

Thaxtomin A is a unique dioxopiperazine containing a 4-nitroindol-3-yl moiety isolated by scientists at Dow Agrisciences from Streptomyces scabies, the causative agent of common scab on new potatoes in 1989. Thaxtomin A is the predominant and most active member of the thaxtomin group of phytotoxins. Thaxtomin A acts as a herbicide via inhibition of cellulose biosynthesis. Atypical programmed cell death induced by thaxtomin A can be ameliorated by hydrogen peroxide. Thaxtomin A dysregulates K+ and Ca2+ fluxes in the roots of Arabidopsis.

References

  • Isolation and characterization of phytotoxins associated with Streptomyces scabies. King R.R. et al. J Chem Soc Chem Commun. 1989, 849. 
  • Herbicidal properties of the thaxtomin group of phytotoxins. King R.R. & Lawrence C.H. J Agric Food Chem. 2001, 49, 2298.
  • Reactive oxygen species alleviate cell death induced by thaxtomin A in Arabidopsis thaliana cell cultures. Awwad F. et al. Plants 2019, 8.

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