$56.00 - 25 mg
$196.00 - 100 mg
All prices in Australian dollars
- HPEK-1, Kelox, NSC 112931, THQ, Terasin
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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Tetrahydroxyquinone is a black pigment isolated from Rubia tinctorum in which all four protons of the benzoquinone structure are substituted by hydroxyl groups. Tetrahydroxyquinone has a role as a radical scavenger and is keratolytic. In vitro, tetrahydroxyquinone induces apopoptosis of leukemia cells by reducing protein kinase B-dependent survival signaling followed by apoptosis through the mitochondrial pathway. Tetrahydroxybenzoquinone is a moderately potent inhibitor of aldose reductase, with an IC50 of 23 μM.
- Free radical scavenging reactions of tetrahydroxyquinone: A pulse radiolysis study. Joshi R. Chemistry Select 2016, 1, 1084.
- The effects of tetrahydroxyquinone on connective tissue. Kelly E.W. J Chronic Dis. 1963, 16, 335.
- Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signalling. Martins C. et al. Experi Hematol. 2006, 34, 188.