Terpendole I

Terpendole I

$240.00 - 1 mg

$840.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1828
Synonyms
TerI
CAS #
167612-17-1
Molecular Formula
C27H35NO5
Molecular Weight
453.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Terpendole I is a polar analogue of a rare family of indolediterpenes isolated from Albophoma yamanashiensis, first reported by Omura and colleagues at the Kitasato Institute, Japan in 1995. Terpendole I is a weak inhibitor of ACAT (acyl-CoA:cholesterol acyltransferase). The biosynthetic gene cluster coding for production of terpendoles was identified in 2012.

References

  • Materials for the fungus flora of Japan (47). Kobayashi T. et al., Mycoscience 1994, 35, 399.
  • Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. Tomoda H. et al., J. Antibiot. 1995, 48, 793.
  • Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba. Motoyama T. et al., Chem. Biol. 2012, 19, 1611.

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