Ternatin
Application Notes
Ternatin is a cyclic peptide antifungal metabolite, first isolated from the fungus Didymocladium ternatum in Russia in 1974. More recently, ternatin has been demonstrated to be a potent inhibitor of fat accumulation in 3T3-L1 murine adipocytes. Note that this metabolite should not be confused with the plant flavonoid of the same name.
References
- Convergent synthesis and in vivo inhibitory effect on fat accumulation of (−)-ternatin, a highly N-methylated cyclic peptide. Shimokawa K. et al., Bioorg. Med. Chem. Lett. 2005, 17, 4447.
- (−)-Ternatin, a highly N-methylated cyclic heptapeptide that inhibits fat accumulation: Structure and synthesis. Shimokawa K. et al., Tet. Lett. 2006, 47, 4445.