T2 toxin

T2 toxin

$189.00 - 0.25 mg

$662.00 - 1 mg

All prices in Australian dollars

Synonyms
Fusariotoxin T 2, Insariotoxin, Mycotoxin T 2, NSC 138780, T 2, T 2 Toxin, T 2 mycotoxin, T-2 Lienomycin, Toxin T 2
CAS #
21259-20-1
Molecular Formula
C24H34O9
Molecular Weight
466.52
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

T2 toxin is a Type A trichothecene mycotoxin found grains infected with Fusarium sp. causing toxic effects in livestock, particularly poultry. T2 toxin possesses an unusual 12,13-epoxytrichothecene-9-ene ring structure that is responsible for its toxicity. T2 toxin is cytotoxic to Vero cells in vitro causing induction of lipid peroxidation, inhibiting protein synthesis and causing​ DNA fragmentation and caspase-​3-​dependent apoptosis. In neuroblastoma cells, T2 toxin inhibits the Nrf2/HO-1 pathway leading to the generation of reactive oxygen species and mitochondrial dysfuntion. T2 toxin has a broad toxicological profile, having nephrotoxic, immunosuppressive and teratogenic effects.

References

  • T-2 toxin: incidence and toxicity in poultry. Sokolović M. et al. Arh Hig Rada Toksikol. 2008, 59, 43.
  • The structure of T-2 toxin. Gilardi R et al. Acta Cryst. 1990, C46, 645.
  • Cytotoxicity and related effects of T-​2 toxin on cultured Vero cells. Bouaziz C. et al. Toxicon. 2006, 48, 343.
  • The nephrotoxicity of T-​2 toxin in mice caused by oxidative stress-​mediated apoptosis is related to Nrf2 pathway. Zhang X. et al. Food Chem Toxicol. 2021, 149, 112027.

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