Sulbactam sodium

Sulbactam sodium

$75.00 - 5 mg

$265.00 - 25 mg

All prices in Australian dollars

Code
BIA-S1565
Synonyms
Penicillanic acid 1,1-dioxide sodium
CAS #
68373-14-8
Molecular Formula
C8H10NNaO5S
Molecular Weight
255.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Sulbactam sodium is a semi-synthetic penem antibiotic formed by the oxidation of penicillanic acid to its sulfone and was invented by Barth at Pfizer in 1978. Sulbactam sodium is a weak antibiotic but its action as an irreversible inhibitor of β-lactamase is exploited to block the degradation of other penicillin derivatives. Sulbactam acts as a synergist with cephalosporins and penicillins against Gram positive bacteria and is used commercially in combination with ampicillin.

References

  • Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors. Barth W.E. US Patent 41,234,579 1980.
  • CP-45,899 in combination with penicillin or ampicillin against penicillin-resistant Staphylococcus, Haemophilus influenzae, and Bacteroides. Retsema J.A. et al., Antimicrob. Agents Chemother. 1980, 17, 615.
  • Sulbactam/Ampicillin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Campoli-Richards D.M. and Brogden R.N. Drugs 1987, 33, 577.

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