Stromemycin

Stromemycin

$250.00 - 1 mg

$875.00 - 5 mg

All prices in Australian dollars

Code
BIA-S3036
Synonyms
BS-1090
CAS #
345295-46-7
Molecular Formula
C38H48O12
Molecular Weight
696.8
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol and DMSO.

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Application Notes

Stromemycin is a C-glycosidic depside produced by a marine-derived Emericella sp. first isolated by Wink and coworkers at Aventis in 2001. Stromemycin inhibits stromelysin (metalloproteinase-3), an enzyme involved in the degradation of proteoglycans, constituents of cartilaginous tissue. Stromemycin has been patented for potential use for the treatment of connective tissue disorders. Due to lack of availability, the pharmacology of stromemycin has not been extensively investigated.

References

  • Bringmann G. et al. (2003). Evariquinone, isoemericellin, and stromemycin from a sponge derived strain of the fungus Emericella variecolor. Phytochem., 63, 437.
  • Hopmann C. et al. (2002). Preparation of stromemycins as stromelysin inhibitors. US Patent 6,337,411B2,.

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