$245.00 - 5 mg
$858.00 - 25 mg
All prices in Australian dollars
- AM 2282, M 193
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
- IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. Peet G.W. et al., J. Biol. Chem. 1999, 274, 32655.
- Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines. Boix J. et al., Neuropharmacology 1997, 36, 811.
- Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Ruegg U.T. et al., Trends Pharmacol. Sci. 1989, 10, 218.