Staurosporine

Staurosporine

$265.00 - 5 mg

$930.00 - 25 mg

All prices in Australian dollars

Code
BIA-S1086
Synonyms
AM 2282, M 193
CAS #
62996-74-1
Molecular Formula
C28H26N4O3
Molecular Weight
466.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.

References

  • IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. Peet G.W. et al., J. Biol. Chem. 1999, 274, 32655.
  • Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines. Boix J. et al., Neuropharmacology 1997, 36, 811.
  • Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Ruegg U.T. et al., Trends Pharmacol. Sci. 1989, 10, 218.

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