Sporidesmolide V is the most non-polar of the N-methyl analogues belonging the hexadepsipeptide sporidesmolide complex. Biosynthesis of sporidesmolide V involves the use of D- and L- amino acids utilising alloisoleucine, isoleucine, leucine, and two valine sub-units, where one of the valines and a leucine are converted to the corresponding valic acid. The biological activity of sporidesmolide V has not been extensively investigated.