Sporidesmolide I is the most polar of N-methyl analogues belonging the hexadepsipeptide sporidesmolide complex. Biosynthesis of sporidesmolide I involves the use of D- and L- amino acids utilising two leucine and four valine sub-units, where two of the valines are converted to the corresponding valic acid. The biological activity of sporidesmolide I has not been extensively investigated.