$233.00 - 1 mg
$816.00 - 5 mg
All prices in Australian dollars
- (+)-Sparsomycin, Sparsogenin B79B, U 19183, NSC 59729
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO.
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Sparsomycin is a nucleotide analogue produced by Streptomyces sparsogenes isolated by researchers at Upjohn (now Pfizer) in 1962. Sparsomycin binds to the 50S ribosomal subunit and inhibits protein synthesis via peptidyl transferase inhibition. Sparsomycin is very active against κβ human epidermoid carcinoma cells in tissue cultures and moderately active against Gram-positive and Gram-negative bacteria and fungi. The biosynthesis of sparsomycin has been extensively studied.
- Sparsomycin, a new antitumor antibiotic. I. Discovery and biological properties. Owen S.P. et al., Antimicrob. Agents Chemother. 1962, 772.
- Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation. Ermolenko D.N. et al., RNA 2013, 19, 158.
- The biosynthesis of sparsomycin. Elucidation of the origins of the carbon skeleton. Parry R.J. & Eudy M.E., J. Am. Chem. Soc. 1988, 110, 2316.