$290.00 - 1 mg
$1,015.00 - 5 mg
All prices in Australian dollars
- CS 280, SI 23548
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Siccanin is an unusual fused phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.
- Studies on antibiotics from Helminthosporium sp. fungi. VII Siccanin, a new antifungal antibiotic produced by Helminthopsporium siccans. Ishibashi K. J. Antibiot. Series A 1962, 15, 161.
- Mode of action of the antibiotic siccanin on intact cells and mitochondria of Trichophyton mentagrophytes. Nose K. & Endo A. J. Bacteriol. 1971, 105, 176.
- Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. Mogi T.J. et al., Biochem. 2009, 146, 383.