Siccanin

Siccanin

$290.00 - 1 mg

$1,015.00 - 5 mg

All prices in Australian dollars

Code
BIA-S1421
Synonyms
CS 280, SI 23548
CAS #
22733-60-4
Molecular Formula
C22H30O3
Molecular Weight
342.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Siccanin is an unusual fused phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.

References

  • Studies on antibiotics from Helminthosporium sp. fungi. VII Siccanin, a new antifungal antibiotic produced by Helminthopsporium siccans. Ishibashi K. J. Antibiot. Series A 1962, 15, 161.
  • Mode of action of the antibiotic siccanin on intact cells and mitochondria of Trichophyton mentagrophytes. Nose K. & Endo A. J. Bacteriol. 1971, 105, 176.
  • Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. Mogi T.J. et al., Biochem. 2009, 146, 383.

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