Scytalone
Application Notes
Scytalone is a trihydroxytetralone first isolated from Scytaladium sp. by Findlay and Kwan, University of New Brunswick, Canada in 1972. Scytalone has subsequently been isolated from a large number of species of diverse fungal genera. Scytalone is a pivotal intermediate of melanin biosynthesis in fungi and is considered to play an integral role in spore structural development and protecting spores from biotic and abiotic stresses.
References
- Findlay J.A. & Kwan D. (1973). Scytalone (3,6,8-trihydroxytetralone), a metabolite from a Scytalidium species. Can. J. Chem., 51, 1617.
- Bell A.A. et al. (1976). Pentaketide metabolites of Verticillium dahliae. Identification of (+)-scytalone as a natural precursor to melanin. Tetrahedron, 32, 1353.
- Zhang P. et al. (2017). A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici. Mol. Microbiol., 105, 469.