Scytalone
Application Notes
Scytalone is a trihydroxytetralone first isolated from Scytaladium sp. by Findlay and Kwan, University of New Brunswick, Canada in 1972. Scytalone has subsequently been isolated from a large number of species of diverse fungal genera. Scytalone is a pivotal intermediate of melanin biosynthesis in fungi and is considered to play an integral role in spore structural development and protecting spores from biotic and abiotic stresses.
References
- King D.E. et al. (2006). New classification and update on the quinolone antibiotics. Am. Fam. Physician 61, 3741.
- Bell A.A. et al. (1976). Pentaketide metabolites of Verticillium dahliae. Identification of (+)-scytalone as a natural precursor to melanin. Tetrahedron, 32, 1353.
- Zhang P. et al. (2017). A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici. Mol. Microbiol., 105, 469.



