Sclerotiorin

Sclerotiorin

$210.00 - 1 mg

$735.00 - 5 mg

All prices in Australian dollars

Code
BIA-S2941
Synonyms
(+)-Sclerotiorin
CAS #
549-23-5
Molecular Formula
C21H23ClO5
Molecular Weight
390.86
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Sclerotiorin is an unusual azaphilone pigment first isolated from Penicillium sclerotiorum by MacCurtin and Reilly, University of Cork, Ireland in 1940. Sclerotiorin has broad biological activity and is a potent aldose reductase (IC50 0.4 µM) and lipoxygenase (IC50 4.2 µM) inhibitor and radical scavenger. Sclerotiorin induces apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and down-regulation of BCL-2. Sclerotiorin has antifungal and antibacterial activity.

References

  • Sclerotiorine, a chlorinated metabolic product of Penicillium sclerotiorum van Beyma. MacCurtin T.P. & Reilly J. Nature 1940, 7, 335.
  • Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase. Chidananda C. et al. Biotech Lett 2006, 28, 1633.
  • Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans. Chidananda C. & Sattur A.P. J Ag Food Chem 2007, 55, 2879.
  • Preparation, structure, and potent antifouling activity of sclerotioramine derivatives. Wei M-Y. et al. Mar Biotech 2017, 19, 372.

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