Sclerotiorin

Sclerotiorin

$230.00 - 1 mg

$805.00 - 5 mg

All prices in Australian dollars

Code
BIA-S2941
Synonyms
(+)-Sclerotiorin
CAS #
549-23-5
Molecular Formula
C21H23ClO5
Molecular Weight
390.86
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Sclerotiorin is an unusual azaphilone pigment first isolated from Penicillium sclerotiorum by MacCurtin and Reilly, University of Cork, Ireland in 1940. Sclerotiorin has broad biological activity and is a potent aldose reductase (IC50 0.4 µM) and lipoxygenase (IC50 4.2 µM) inhibitor and radical scavenger. Sclerotiorin induces apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and down-regulation of BCL-2. Sclerotiorin has antifungal and antibacterial activity.

References

  • Sclerotiorine, a chlorinated metabolic product of Penicillium sclerotiorum van Beyma. MacCurtin T.P. & Reilly J. Nature 1940, 7, 335.
  • Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase. Chidananda C. et al. Biotech Lett 2006, 28, 1633.
  • Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans. Chidananda C. & Sattur A.P. J Ag Food Chem 2007, 55, 2879.
  • Preparation, structure, and potent antifouling activity of sclerotioramine derivatives. Wei M-Y. et al. Mar Biotech 2017, 19, 372.

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