Ridaforolimus

Ridaforolimus

$170.00 - 1 mg

$595.00 - 5 mg

All prices in Australian dollars

Code
BIA-R1450
Synonyms
AP 23573, MK 8669, 42-Dimethylphosphinate-rapamycin
CAS #
572924-54-0
Molecular Formula
C53H84NO14P
Molecular Weight
990.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Application Notes

Ridaforolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety. Like all tacrolimus analogues, ridaforolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing its interaction with target proteins. Ridaforolimus is extensively cited in the literature with over 70 citations.

References

  • Phosphorus-containing compounds and uses thereof. Metcalf C.A. et al., US Patent 7,091,213, 2006.
  • Targeting the mTOR pathway using deforolimus in cancer therapy. Mahalingam D. et al., Future Oncol. 2009, 5, 291.

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