Rebeccamycin

Rebeccamycin

$295.00 - 0.50 mg

$1,035.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-R1075
CAS #
93908-02-2
Molecular Formula
C27H21Cl2N3O7
Molecular Weight
570.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. Rebeccamycin displays selective antitumor activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebeccamycin have been tested in clinical trials for cancer therapy.

References

  • Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Long B. H., et al., Curr. Med. Chem. Anticancer Agents, 2002, 2, 255.
  • Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin. Woo M. H., et al., J. Biol. Chem., 2002, 277, 3813.
  • Production and biological activity of rebeccamycin, a novel antitumor agent. Bush J. A., et al., J. Antibiot., 1987, 40, 668.

Other Products

Related products