Pyroglutamic acid, D-

Pyroglutamic acid, D-

$65.00 - 1 mg

$230.00 - 5 mg

All prices in Australian dollars

Code
BIA-P2215
Synonyms
5-Oxo-D-proline, (2R)-5-Oxopyrrolidine-2-carboxylic acid
CAS #
4042-36-8
Molecular Formula
C5H7NO3
Molecular Weight
129.11
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

D-Pyroglutamic acid (5-oxo-D-proline, (R)-5-oxopyrrolidine-2-carboxylic acid) ) is a naturally occurring γ-lactam also formed by the thermal head-to-tail cyclisation of D-glutamic acid. Increased serum levels of D-pyroglutamic acid are associated with nascent metabolic syndrome and renal failure. D-Pyroglutamic acid has been used as a synthon but its pharmacological profile has attracted little interest.

References

  • Accumulation of 5-oxo-L-proline and 5-oxo-D-proline in the blood plasma in end stage renal disease. Palekar A.G. et al. Biochem Med. 1975, 14, 339.
  • D-Glutamate is metabolized in the heart mitochondria. Ayoshi M. et al. Sci Rep. 2017, 7, 43911.
  • Exploratory metabolomics of nascent metabolic syndrome. Shim K. et al. J Diab Compl. 2019, 33, 212.

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