Pyripyropene A

Pyripyropene A

$300.00 - 1 mg

$1,050.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1807
Synonyms
(+)-Pyripyropene A, FO 1289A
CAS #
147444-03-9
Molecular Formula
C31H37NO10
Molecular Weight
583.63
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at The Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol O-acyltransferase 2 (SOAT2) inhibitory activity, thus inhibiting the conversion of cholesterol to cholesteryl esters. Pyripyropene A is active against aphids in field trials and has weak insect anti-feedant activity.

References

  • Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. Omura S. et al., J. Antibiot. 1993, 46, 1168.
  • Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D. Kim Y.K. et al., J. Antibiot. 1994, 47, 154.
  • Design and synthesis of A-ring simplified pyripyropene A analogues as potent and selective synthetic SOAT2 inhibitors. Ohtawa M. et al., Chem. Med. Chem. 2018, 13, 411.

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