Pyoverdine

Pyoverdine

Pyoverdine

$315.00 - 1 mg

$1,105.00 - 5 mg

All prices in Australian dollars

Code
BIA-P3125
Synonyms
Pyoverdin
CAS #
8062-00-8
Molecular Formula
C55H85N17O22 (for succinate)
Molecular Weight
1336.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO.

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Product Data Sheet

Application Notes

Pyoverdine is a complex of polar yellow-green pigments first reported by Gessard, Pasteur Institute, France in 1892. The pigment class comprises >100 analogues produced by a large number of Pseudomonas strains, with Pyoverdine Group I produced by Pseudomonas aeruginosa PA01. Structurally pyoverdine group I is an octapeptide bound to a 2,3-diamino-6,7-dihydroxyquinoline derived chromophore. The core structure is coupled to a Krebbs cycle acid (succinate, fumarate, malate etc.). Pyoverdine is a primary virulence factor of the human pathogenic bacterium Pseudomonas aeruginosa, acting as a siderophore and a virulence-related signal molecule. Pyoverdine plays an important role for the bacterial growth under iron-limited conditions.

References

  • Gessard MC (1892). Sur la fonction fluorescigène des microbes. In: Annales de l’Institut Pasteur. (Institut Pasteur, Eds), pp. 801–823. Masson, Paris.
  • The structure of pyoverdine Pa, the siderophore of Pseudomonas aeruginosa. Wendenbaum S. et al. Tetrahedron Lett. 1983, 24, 4877.
  • Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa. Imperi F. et al. Proc. Nat. Acad. Sci. 2009, 106. 20440.
  • Biosynthesis of novel pyoverdines by domain substitution in a nonribosomal peptide synthetase of Pseudomonas aeruginosa. Appl. Env. Microbiol. 2014, 80, 5723.

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