Pimecrolimus

Pimecrolimus

$101.00 - 1 mg

$354.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1385
CAS #
137071-32-0
Molecular Formula
C43H68ClNO11
Molecular Weight
810.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Application Notes

Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Pimecrolimus is extensively cited in the literature with over 2,000 citations.

References

  • Method for preparing pimecrolimus. Gyollai V. & Szabo C. US Patent 7,279,571, 2007.
  • Pimecrolimus. Novartis. Schopf R.E. Curr. Opin. Investig. Drugs 2002, 3, 720.

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