Phomopsinamine

Phomopsinamine

$158.00 - 0.10 mg

$553.00 - 0.50 mg

All prices in Australian dollars

Synonyms
Phomopsinamine A
CAS #
89085-54-1
Molecular Formula
C32H43ClN6O8
Molecular Weight
675.17
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Phomopsinamine is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis. Phomopsinamine is formed by hydrolysis of the dicarboxylic acid of phomopsin A. The phomopsins cause lupinosis in livestock fed infected lupins. Phomopsinamine is a potent microtubule inhibitor, blocking the polymerization of tubulin at a concentration of less than 1 µM by binding selectively to dimeric tubulin at a site overlapping that of vinblastine and maytansine.

References

  • The chemical and biological properties of phomopsin. Frahn J.L. et al. Toxicon. 1983, Suppl. 3, 149. 
  • Interaction of phomopsin A and related compounds with purified sheep brain tubulin. Lacey E. et al. Biochem Pharmacol. 1987, 36, 2133.

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