Pepstatin A

Pepstatin A

$110.00 - 0.50 mg

$385.00 - 2.50 mg

All prices in Australian dollars

Ahpatinin C, NSC 272671, Pepsin inhibitor S 735A Pepstatin, Procidin S 735A
Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Application Notes

Pepstatin A, a pentapeptide isolated from Streptomyces sp. is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. Pepstatin is active against HIV-1 and Plasmodium falciparum. HIV-infected H9 cells incubated with pepstatin A at 10-4M for 2, 4 or 10 days had significantly reduced HIV core antigen (p24) and no infectious HIV. Pepstatin A exerts its antimalarial activity via P. falciparum plasmepsin II binding sites. Pepstatin A suppresses NF-​κB ligand (RANKL)​-​induced osteoclast differentiation and decreases the expression of nuclear factor of activated T cells c1 (NFATc1)​, suggesting that suppresses the differentiation of osteoclasts through the blockade of ERK signaling and the inhibition of NFATc1 expression.


  • Pepstatin, a new pepsin inhibitor produced by Actinomycetes. Umezawa H. et al. J Antibiot. 1970, XXIII, 259.
  • Inhibition of HIV replication in cell culture by the specific aspartic protease inhibitor pepstatin A. von der Helm K. et al. FEBS Lett. 1989, 247, 349.
  • Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria. Andrews K.T. et al. Atnimicrob Agents Chemother. 2006, 50, 639.

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