Penisimplicissin
Penisimplicissin
$265.00 - 0.5 mg
$930.00 - 2.5 mg
All prices in Australian dollars
- Code
- BIA-P3129
- Synonyms
- -
- CAS #
- 873207-55-7
- Molecular Formula
- C16H14O6
- Molecular Weight
- 302.3
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in methanol, DMSO.
Download Data Sheets
Application Notes
Penisimplicissin is a benzofuranone, related to vermistatin, originally isolated from Penicillium simplicissimum by Japanese ressearchers and published in 2005. Penisimplicissin is also produced by the extremophilic fungus, Penicillium rubrum. Penisimplicissin is a selective inhibitor of leukemia cell lines acting via inhibition of caspase-1 and is active against the canine coronavirus.
References
- New vermistatin derivatives isolated from Penicillium simplicissimum. Komai S-I. et al. Heterocycles 2005, 65, 2771.
- Caspase-1 inhibitors from an extremophilic fungus that target specific leukemia cell lines. Stierle A.A. et al. J. Nat. Prod. 2012, 75, 344.
- In vitro evaluation of antiviral activities of funicone-like compounds vermistatin and penisimplicissin against canine coronavirus infection. Cerracchio C. et al. Antibiotics 2023, 12, 1319.
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