Penicolinate A
Application Notes
Penicolinate A, a bis-picolinic ester linked by a decamethylene bridge, was first isolated from Penicillium sp. BCC16054 by researchers at BIOTEC, Thailand in 2013. Penicolinate A is active against malaria, mycobacteria and mammalian tumor cell lines. Structurally, penicolinate A represents a “dimeric” ester of the antibiotic, fusaric acid. This dimerization affords a much broader bioprofile than that of fusaric acid.
References
- Penicolinates A–E from endophytic Penicillium sp. BCC16054. Intaraudom C. et al., Tet. Lett. 2013, 54, 744.