Paraherquamide E

Paraherquamide E

$350.00 - 0.50 mg

$1,225.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-P1118
Synonyms
VM 54159, 14-Deoxyparaherquamide A
CAS #
125600-53-5
Molecular Formula
C28H35N3O4
Molecular Weight
477.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Paraherquamide E is a member of the paraherquamide family which causes a potent non-toxic paralysis of nematodes and has led to investigation as potential anthelmintics. Although paraherquamide A has received more attention, paraherquamide E is the more potent anthelmintic in vivo. Paraherquamide E was found to be the most potent of a series of paraherquamide analogues tested for insecticidal activity against a hemipteran, with an LD50 of 0.089 μg/nymph.

References

  • Insecticidal activity of paraherquamides, including paraherquamide H and paraherquamide I, two new alkaloids isolated from Penicillium cluniae. Lopez-Gresa M.P. et al., J. Agric. Food Chem. 2006, 54, 2921.
  • Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle. Robertson A.P. et al., J. Pharmacol. Exp. Ther. 2002, 302, 853. et al., J. Antibiot. 1991, 44, 492.
  • New paraherquamide antibiotics with anthelmintic activity. Blanchflower S.E.

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