Paraherquamide A

Paraherquamide A

$350.00 - 1 mg

$1,225.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1065
Synonyms
VM 29919
CAS #
77392-58-6
Molecular Formula
C28H35N3O5
Molecular Weight
493.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

References

  • The structure of parherquamide, a toxic metabolite from Penicillium paraherquei. Yamazaki M.E. et al., Tetrahedron Lett. 1982, 22, 135.
  • Novel antinematocidal and antiparasitic agents from Penicillium charlesii I. Fermentation, isolation and biological activity. Ondeyka J.G. J. Antibiot. 1990, 43, 1375.
  • Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle. Robertson A.P. et al., J. Pharmacol. Exp. Ther. 2002, 302, 853.

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