Oxindole

Oxindole

$65.00 - 5 mg

$230.00 - 25 mg

All prices in Australian dollars

Code
BIA-O1735
Synonyms
2-Indolinone, 2-Hydroxyindole
CAS #
59-48-3
Molecular Formula
C8H7NO
Molecular Weight
133.15
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Oxindole is a simple indole analogue isolated from both bacteria (Chromobacterium violaceum) and fungi (a basidiomycete, Calyptella sp. and an ascomycete, Pencillium sp.). Oxindole exists as the dominant tautomer of 2-hydroxyindole both in solution and as a solid. Oxindole has been reported as an inhibitor of phospholipase A2 and platelet aggregation. Its unusual distribution in microbes makes oxindole a useful standard for analytical and bioassay dereplication of crude microbial extracts.

References

  • Bacterial chemistry. VI. Biological activities and cytotoxicity of l,3-dihydro-2H-indol-2-one derivatives. Haun M. et al., Biol. Res. 1992, 25, 21.
  • 5-Hydroxy-3-vinyl-2(5H)-furanone, a new inhibitor of human synovial phospholipase A2 and platelet aggregation from fermentations of a Calyptella species (Basidiomycetes). Lorenzen K. et al., Z. Naturforsch. 1995, 50c, 403.
  • A new inhibitor of synovial phospholipase A2 from fermentations of Penicillium sp. 62-92. Witter L. et al., Z. Naturforsch. 1998, 53c, 60.

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