Onychocin B
Onychocin B
$180.00 - 0.25 mg
$630.00 - 1 mg
All prices in Australian dollars
- Code
- BIA-O2365
- CAS #
- NA
- Molecular Formula
- C31H42N4O4
- Molecular Weight
- 534.7
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in methanol or DMSO
Download Data Sheets
Application Notes
Onychocin B is an N-methylated cyclotetrapeptide, similar in structure to hirsutide, originally isolated from the fungus Onychocola sclerotic. Onychocin B is a cardiac calcium channel blocker but does not inhibit the hERG potassium channel. Onychocin B moderately inhibits the proliferation of mouse myeloma cells in a dose-dependent manner with an IC50 of 23.1 µg/mL.
References
- Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotic. Pérez-Victoria I. et al. J Nat Prod. 2012, 75, 1210.
- Cyclization of linear tetrapeptides containing N-methylated amino acids by using 1-propanephosphonic acid anhydride. Zhang S. et al. Eur J Org Chem. 2017, 2017, 149.
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