Novobiocin

Novobiocin

$150.00 - 5 mg

$525.00 - 25 mg

All prices in Australian dollars

Code
BIA-N1306
Synonyms
Albamycin, Vulcamycin, PA 93, WS 6629, Griseoflavin, S 800.
CAS #
303-81-1
Molecular Formula
C31H36N2O11
Molecular Weight
612.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram positive antibiotic activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and a competitive inhibitor of the ATPase reaction catalysed by GyrB.

References

  • The structure of novobiocin. Hinman J. W. et al., JACS 1957, 79, 3789.
  • Novobiocin II. Structure of novobiocin. Shunk C.H. et al., JACS 1956, 78, 1770.
  • A novel homogenous assay for topoisomerase II action and inhibition. Jahnz M. et al., Chem. Biochem. 2005, 6, 920.
  • Investigations of the biosynthesis of novobiocin. Calvert R. T. et al., J. Pharm. Pharmacol. 1972, 24, 972.

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