Nivalenol

Nivalenol

$235.00 - 0.10 mg

$825.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-N1920
Synonyms
NSC 269143
CAS #
23282-20-4
Molecular Formula
C15H20O7
Molecular Weight
312.32
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Nivalenol is a trichothecene mycotoxin produced by various Fusarium sp. infecting grains. Nivalenol inhibits protein synthesis in H-HeLa cells, causing rapid and almost quantitative breakdown of polyribosomes. Nivalenol induces apoptosis mediated by caspase-3 and is associated with a cell cycle blocking in G0/G1 phase. Nivalenol demonstrates time-dependent inhibition followed by stimulation of interleukin (IL)​-​2, IL-​4 and IL-​5 in concanavalin A-treated CD4+ T-​cells.

References

  • Toxicological research on substances from fusarium nivale III: The structure of nivalenol and its monoacetate. Tatsuno T. et al. Tetrahedron Lett. 1969, 10, 2823.
  • Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. Cundliffe E. et al. Proc Nat Acad Sci. 1974, 71, 30.
  • Pro-apoptotic effects of nivalenol and deoxynivalenol trichothecenes in J774A.1 murine macrophages. Marzocco S. et al. Toxicology Lett. 2009, 189, 21.
  • Effects of trichothecene mycotoxins on eukaryotic cells: A review. Rocha O. et al. Food Add Contam. 2005, 22, 369.

Other Products

Related products